Himandridine

Himandridine

$199.00 - 0.50 mg

$697.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-H1746
Synonyms
Himandreline, NSC 23972
CAS #
15521-76-3
Molecular Formula
C30H37NO7
Molecular Weight
523.62
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Application Notes

Himandridine is a piperidine alkaloid with a complex polycyclic scaffold first isolated from Galbulimia sp., a magnolia native to northern Australia and South East Asia, and reported in 1967 by Ritchie and co-workers, University of Sydney, Australia. There are no specific reports of himandridine’s biological activity, however the related himbacine and analogues inhibit muscarinic receptors with 10-fold selectivity for M2 over M1 receptors.

References

  • The chemical constituents of Himantandra species. II. The isolation of the alkaloids of Himantandra baccata and Himantandra belgraveana. Brown R.F.C. et al., Aust. J. Chem. 1956, 9, 283.
  • Progress toward the syntheses of (+)-GB 13, (+)-himgaline, and himandridine. New insights into intramolecular imine/enamine aldol cyclizations. Evans D.A. et al., J. Am. Chem. Soc. 2012, 134, 8162.
  • Himbacine analogs as muscarinic receptor antagonists - effects of tether and heterocyclic variations. Chackalamannil S. et al., Bioorg. Med. Chem. Lett. 2004, 15, 3967.

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