Himandridine
Application Notes
Himandridine is a piperidine alkaloid with a complex polycyclic scaffold first isolated from Galbulimia sp., a magnolia native to northern Australia and South East Asia, and reported in 1967 by Ritchie and co-workers, University of Sydney, Australia. There are no specific reports of himandridine’s biological activity, however the related himbacine and analogues inhibit muscarinic receptors with 10-fold selectivity for M2 over M1 receptors.
References
- The chemical constituents of Himantandra species. II. The isolation of the alkaloids of Himantandra baccata and Himantandra belgraveana. Brown R.F.C. et al., Aust. J. Chem. 1956, 9, 283.
- Progress toward the syntheses of (+)-GB 13, (+)-himgaline, and himandridine. New insights into intramolecular imine/enamine aldol cyclizations. Evans D.A. et al., J. Am. Chem. Soc. 2012, 134, 8162.
- Himbacine analogs as muscarinic receptor antagonists - effects of tether and heterocyclic variations. Chackalamannil S. et al., Bioorg. Med. Chem. Lett. 2004, 15, 3967.