Herbimycin C

Herbimycin C

$287.00 - 0.50 mg

$1,005.00 - 2.50 mg

All prices in Australian dollars

Synonyms
TAN 420D
CAS #
91700-92-4
Molecular Formula
C29H40N2O9
Molecular Weight
560.6
Purity
>98% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Clear

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Application Notes

Herbimycin C is a minor analogue of the herbimycin complex isolated from Streptomyces hygroscopicus. Herbimycin C possesses potent antitumor activity and converts Rous sarcoma virus-infected rat kidney cells into normal cells. Until now limited access has restricted a full investigation of the properties of herbimycin C. Research on related metabolites, herbimycin A and geldanamycin, has stimulated intensive interest in this class as selective antitumor agents and for prolonging the viability of tissue-cultured cells and organs.

References

  • The structure and cytocidal activity of herbimycin C. Shibata K. et al., J. Antibiot. 1986, 39, 1630.
  • Natural product origins of Hsp90 inhibitors. Uehara Y. Curr. Cancer Drug Targets 2003, 3, 325.
  • Inducement of thermotolerance with benzoquinonoid ansamycins. Welch W.J. 2000 US Patent 6015659.

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