Helvolic acid is a triterpenoid antibacterial mycotoxin produced by Aspergillus and other fungal species, structurally related to cephalosporin P1 and fusidic acid. Helvolic acid is active against Gram positive and Gram negative organisms, including Clostrium pseudomonas, Mycobacterium shigella, Salmonella typhimurium and Corynebacterium. Helvolic acid is a strong synergist of penicillin against multidrug resistant S. aureus. Helvolic acid has antitumor, antitrypanosomal, antimycobacterial and potent antiviral activity against H. pylori.
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