Luzopeptin A

Luzopeptin A

$215.00 - 0.50 mg

$755.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-L1139
Synonyms
BBM-928A
CAS #
75580-37-9
Molecular Formula
C64H78N14O24
Molecular Weight
1427.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Luzopeptin A is a member of the echinomycin (quinomycin A) class of antitumor and antibiotic agents that act by forming a stable DNA complex by bis-intercalation. Luzopeptin A is also a potent inhibitor of HIV-1 reverse transcriptase.

References

  • BBM-928, a new antitumor antibiotic complex I. Production, isolation, characterization and antitumor activity. Ohkuma, H. et al., J. Antibiot. 1980, 33, 1087.
  • Screening for inhibitors of avian myeloblastosis virus reverse transcriptase and effect on the replication of AIDS virus. Inouye Y.J. Antibiot. 1987, 40, 100.
  • Proton exchange in DNA-luzopeptin and DNA-echinomycin bisintercalation complexes: rates and processes of base-pair opening. Leroy J.L. et al., Biochemistry. 1992, 31, 1407.

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