Fusaric acid was isolated as a phytotoxin from Fusarium heterosporium by Yabuta and colleagues in 1934. Fusaric acid is a picolinic acid derivative that displays a broad range of activity against Gram positive and Gram negative bacteria, fungi, yeast and mammalian tumor cell lines. Re-discovery of fusaric acid as a hypotensive agent, acting via potent inhibition of dopamine β-hydroxylase, has sustained interest in fusaric acid as an experimental reagent.