Florfenicol

Florfenicol

$195.00 - 25 mg

$55.00 - 5 mg

All prices in Australian dollars

Code
BIA-F1487
Synonyms
(-)Florfenicol, Sch 25298
CAS #
73231-34-2
Molecular Formula
C12H14Cl2FNO4S
Molecular Weight
358.2
Purity
>95% by HPLC
Long Term Storage
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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Product Data Sheet

Application Notes

Florfenicol is synthesised from thiamphenicol by replacing the 3-hydroxy group with fluorine, first synthesised at Schering in 1980. By replacing the hydroxy group, it was rationalised that chloramphenicol resistance via chloramphenicol acetyltransferase could be eliminated. Florfenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Florfenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Florfenicol has been extensively studied with over 400 literature citations.

References

  • An efficient synthesis of florfenicol. Schumacher D.P. et al., J. Org. Chem. 1990, 55, 5291.
  • An improved industrial synthesis of florfenicol plus an enantioselective total synthesis of thiamphenicol and florfenicol Wu G. et al., J. Org. Chem. 1997, 62, 2996.
  • In vitro activity of chloramphenicol and thiamphenicol analogs. Neu H.C. & Fu K.P. Antimicrob. Agents Chemother. 1980, 18, 311.

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