FI-3

FI-3

$200.00 - 0.25 mg

$700.00 - 1 mg

All prices in Australian dollars

Code
BIA-F2934
Synonyms
Antibiotic FI-3
CAS #
-
Molecular Formula
C29H36N2O5
Molecular Weight
492.62
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Application Notes

Antibiotic FI-3 is a rare tetramic acid antibiotic first reported in 2010 as a biosynthetic intermediate of the frontalamides by Clardy and co-workers at Harvard. FI-3 is active against Gram positive bacteria including methicillin sensitive and methicillin resistant S. aureus (MIC 32 and 128 µg/mL, respectively). FI-3 disrupts biofilm adherence at 64 µg/mL. FI-3 enhances the activity of tetracycline, gentamicin and vancomycin against S. aureus.

References

  • Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria. Blodgetta J.A.V. et al. Proc Nat Acad Sci 2010, 107, 11692.
  • Fungal-derived xenobiotic exhibits antibacterial and antibiofilm activity against Staphylococcus aureus. Kumar S. et al. Drug Discov Ther 2018, 12, 214.

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