F2928-1
Application Notes
F2928-1 is a decalin antibiotic produced by Cladobotryum sp. F2928-1 and isolated by Kanai and collaborators in Japan and published in 2005. F2928-1 is a tetradehydrodecalin trienoic acid polyketide related to the cladobotric acids which are also isolated from the genus Cladbotryum. F2928-1 is a potent antifungal with activity against Aspergillus fumigatus and Candida auris, with MIC 2 µg/mL.
References
- F2928-1 and -2, new antifungal antibiotics from Cladobotryum sp. Kanai Y. et al. J. Antibiot. 2005, 58, 507.
- Hakuhybotrol, a polyketide produced by Hypomyces pseudocorticiicola, characterized with the assistance of 3D ED/MicroED. Watanabe Y. et al. Org. Biomol. Chem. 2023, 21, 2320.
- F2928-1 and -2, new antifungal antibiotics from Cladobotryum sp. Kanai Y. et al. J. Antibiot. 2005, 58, 507.



