$67.00 - 5 mg
$235.00 - 25 mg
All prices in Australian dollars
- (-)-Eserine, (-)-Physostigmine, Cogmine, Esromiotin, MCV 4484, NIH 10421, NSC 30782, Physostol
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in methanol or DMSO
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Eserine (physostigmine) was isolated from the Calabar bean in 1878 and its structure first elucidated in 1925 and subsequently revised in 1973. Eserine inhibits acetylcholinesterase, indirectly stimulating both nicotinic and muscarinic receptors due to the consequential increase in available acetylcholine at the synapse. Eserine acts allosterically as a noncompetitive sensitizer of acetylcholine in the rat heart.
- Cholinesterase inhibitors: Structure of eserine. Petcher T.J. & Pauling P. Nature 1973, 241, 277.
- The mechanism of action of physostigmine at muscarinic receptors of rat myocardium. Orsetti M. Bollettino - Societa Italiana di Biologia Sperimentale 1986, 62, 67.
- PET imaging of acetylcholinesterase inhibitor-induced effects on α4β2 nicotinic acetylcholine receptor binding. Hillmer A.T. et al. Synapse 2013, 67, 882.