Erythromycylamine

Erythromycylamine

$132.00 - 1 mg

$462.00 - 5 mg

All prices in Australian dollars

Code
BIA-E1517
Synonyms
9(S) Erythromycylamin A, BRL 42852ER, LY 024410
CAS #
26116-56-3
Molecular Formula
C37H70N2O12
Molecular Weight
735
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Good water solubility.

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Product Data Sheet

Application Notes

Erythromycylamine is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. Erythromycylamine is a potent antibiotic, however the introduction of the amino- moiety increases the compound’s polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine.

References

  • Erythromycin. VIII. Structure of dihydroerythronolide. Gerzon K. et al., J. Am. Chem. Soc. 1956, 78, 6396
  • Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136: LY237216), a new macrolide antibiotic derived from erythromycin. Counter F.T. et al., Antimicrob. Agents Chemother. 1991, 35, 1116.
  • Dirithromycin: Introduction and historical development. Kirst H.A. Drugs Today 1995, 31, 89.

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