Erythromycin A N-oxide

Erythromycin A N-oxide

$110.00 - 5 mg

$385.00 - 25 mg

All prices in Australian dollars

Code
BIA-E1539
Synonyms
Erythromycin N-oxide
CAS #
992-65-4
Molecular Formula
C37H67NO14
Molecular Weight
749.9
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Moderate water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Erythromycin A N-oxide is a minor analogue of the erythromycin complex isolated from Saccharopolyspora erythraea. The N-oxide is a facile metabolite formed in vivo which can revert to erythromycin A under reducing conditions. Despite its synthetic preparation in the 1950s, the biological activity of erythromycin A N-oxide has not been extensively studied.

References

  • Erythromycin. I. Properties and degradation studies. Flynn E.H. et al., J. Am. Chem. Soc. 1954, 76, 3121.
  • Cosynthesis of erythromycin A N-oxide by mutants of Saccharopolyspora erythraea blocked in erythromycin production. Bluauerova M. et al., Folia Microbiol. 1991, 36, 533.
  • Isolation of erythromycin A N-oxide and pseudoerythromycin A hemiketal from fermentation broth of Saccharopolyspora erythraea by thin-layer and high-performance liquid chromatography. Beran M. et al., J. Chromatography A 1991, 558, 265.

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