Eprinomectin B1a

Eprinomectin B1a

$300.00 - 1 mg

$1,050.00 - 5 mg

All prices in Australian dollars

Molecular Formula
Molecular Weight
>95% by HPLC
Long Term Storage
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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Application Notes

Eprinomectin B1a is a semi-synthetic analogue of avermectin B1a prepared by oxidation of the 4”-hydroxy moiety and reductive amination followed by acetylation. Eprinomectin B1a is the major component (>90%) of the commercial product for endo- and exo-parasite control, eprinomectin. Members of the avermectin/milbemycin class exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. The avermectins and milbemycins are also potent insecticides and acaricides.


  • 4-Keto- and 4-amino-4-deoxy avermectin compounds and substituted amino derivatives thereof. Mrozik H.H. et al., 1984 US Patent 4,427,663.
  • Synthesis of 4"-epi-amino-4"-deoxyavermectins B1. Cvetovich R.J. et al., J. Org. Chem. 1994, 59, 7704.
  • Efficacy in sheep and pharmacokinetics in cattle that led to the selection of eprinomectin as a topical endectocide for cattle. Shoop W.L. et al., Int. J. Parasitol. 1996, 26, 1227.

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