Epothilone B

Epothilone B

$290.00 - 0.50 mg

$1,015.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-E1255
Synonyms
EpoB
CAS #
152044-54-7
Molecular Formula
C27H41NO6S
Molecular Weight
507.7
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Epothilone B is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Like epothilone A, epothilone B acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.

References

  • Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (myxobacteria) production, physico-chemical and biological properties. Gerth K. et al., J. Antibiot. (Tokyo) 1996, 49, 560.
  • Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Bollag D. M. et al., Cancer Res. 1995, 55, 2325.

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