ent-Rhizocarpic acid
Application Notes
ent-Rhizocarpic acid is the D-isomer of the naturally-occurring L-isomer, rhizocarpic acid. ent-Rhizocarpic acid is a member of the pulvinic acid family, with a tetronic acid core bound to the methyl ester of D-phenylalanine. While rhizocarpic acid has moderate but selective activity against the murine myeloma cell line NS-1, ent-rhizocarpic acid is 10-fold less potent in this assay.
References
- Frank R.L. et al. (1950). The structures and syntheses of rhizocarpic acid and epanorin. J. Am. Chem. Soc., 72, 4454.
- James P.J.C. et al. (2023). Synthesis, characterization, and bioactivity of the lichen pigments pulvinamide, rhizocarpic acid, and epanorin and congeners. J. Nat. Prod., 86, 550.