Enopeptin methyl ester, apo-
apo-Enopeptin methyl ester is the ring-opened derivative of enopeptin. The activity of apo-enopeptin methyl ester is little known, however its parent, enopeptin A, is active against bacteriophage has potent antibacterial activity against Gram positive and Gram negative bacteria, including MRSA. Enopeptin A is the most non-polar of the acyldepsipeptide (ADEP) antibiotics which include the recently rediscovered compounds, A54556 A and B, that act by activating and disregulating Clp-family proteins.
- Diversity oriented synthesis of enopeptins and their use as antibacterials. Sello J.K. PCT Int. Appl. 2012, WO 2012135615 A2 20121004.
- Enopeptin A, a novel depsipeptide antibiotic with anti-bacteriophage activity. Osada H. et al., J. Antibiot. 1991, 44, 1436.
- Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Lee B-G. et al., Nature Struct Mol Biol. 2010, 17, 471.