Duclauxin

Duclauxin

$225.00 - 0.50 mg

$790.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-D1667
Synonyms
NSC 258308
CAS #
1732-37-2
Molecular Formula
C29H22O11
Molecular Weight
546.48
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Product Data Sheet

Application Notes

Duclauxin is a dimeric oxaphenalenone isolated from Penicillium duclauxii by researchers at Tokyo University in 1965. The structure of duclauxin was determined by X-ray crystallography of bromoduclauxin. Duclauxin inhibits mammalian tumor cell line growth and appears to act as a potent uncoupler of oxidative phosphorylation. Duclauxin is a useful standard for chemotaxonomy of Penicillium and Talaromyces species.

References

  • Duclauxin, a metabolite of Penicillium duclauxi (Delacroix). Shibata S. et al., Tet. Lett. 1965, 6, 1287.
  • The crystal and molecular structure of monobromoduclauxin. Ogihara Y. et al., Acta Crystallogr. Sect. B: Struct. Crystallogr. Cryst. Chem. 1968, 24, 1037.
  • In vitro effect of duclauxin and derivatives of coumarin on nucleic acid and protein synthesis in Ehrlich’s ascites carcinoma cells. Fusakova A. et al., Pharmazie 1977, 32, 291.
  • Dereplication of microbial natural products by LC-DAD-TOFMS. Nielsen K.F. et al., J. Nat. Prod. 2011, 74, 2338.

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