$233.00 - 1 mg
$816.00 - 5 mg
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- Alvespimycin, DMAG, NSC 707545, 17-DMAG
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in methanol or DMSO
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17-Dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG, alvespimycin) is a semi-synthetic derivative of the benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group. DMAG acts by binding to the 90-kDa heat shock protein (Hsp90) essential to maintain the conformation, stability, activity and cellular localisation of several key oncogenic proteins such as ERBB2, C-RAF, CDK4, AKT/PKB, steroid hormone receptors, mutant p53, HIF-1α, survivin and telomerase hTERT. DMAG is more potent than geldanamycin and 17-allylamino-17-demethoxygeldanamycin (17AAG) as an inhibitor of Hsp90.
- Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90. Schneider C. et al., Proc Natl Acad Sci. 1996, 93, 14536.
- Mechanistic studies on Hsp90 inhibition by ansamycin derivatives. Onuoha S.C. et al. J Mol Biol. 2007, 372, 287.
- Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models. Smith V. et al. Cancer Chemother Pharmacol. 2005, 56, 126.