Derquantel
Derquantel
$300.00 - 5 mg
$1,050.00 - 25 mg
All prices in Australian dollars
- Code
- BIA-D1514
- Synonyms
- 2-Deoxoparaherquamide, 2-Deoxoparaherquamide A, 2-Desoxoparaherquamide A, PF 00520904, PNU 141962
- CAS #
- 187865-22-1
- Molecular Formula
- C28H37N3O4
- Molecular Weight
- 479.6
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
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Application Notes
Derquantel is a semi-synthetic paraherquamide analogue prepared by removal of the 2-oxo group in a four-step sequence of N-protection, reduction, N-deprotection and a final reduction. Derquantel is a potent nematocide and was the first paraherquamide to be successfully commercialised in combination with avermectin. Derquantel, like other paraherquamides, induces a flaccid paralysis in nematodes thought to be due to inhibition of nicotinic acetylcholine receptors acting as an antagonist of acetylcholine.
References
- Ligands of the nicotinic acetylcholine receptor as insecticides. Nauen R. et al., Pestic. Sci. 1999, 55, 608-610.
- Semisynthesis of 2-deoxo- and 3-epi-paraherquamide A. Lee B.H. et al., Bioorg. Med. Chem. Lett. 2001, 11, 553-554.
- Marcfortine and paraherquamide class of anthelmintics: Discovery of PNU-141962. Lee B.H. et al., Current Topics in Med. Chem. 2002, 2, 779.