Deoxygerfelin
Application Notes
Deoxygerfelin was isolated from a mutagen-treated strain of Aspergillus fumigatus that failed to produce fumigatin and spinulosin, by researchers at Kanazawa University, Japan in 1972. Deoxygerfelin is closely related to gerfelin, a metabolite isolated from Beaveria felina as a geranylgeranyl diphosphatate synthase inhibitor. The biological profile of deoxygerfelin is largely unexplored.
References
- Metabolic products of a strain of Aspergillus fumigatus DH 413. V. New metabolite produced by ethionine inhibition. Yamamoto Y. et al., Chem. Pharm. Bull. 1972, 20, 931.
- Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities. Zenitani S. et al., J. Antibiot. 2003, 56, 617.