Demethylgriseofulvin, 6-O-

Demethylgriseofulvin, 6-O-

$177.00 - 0.25 mg

$620.00 - 1 mg

All prices in Australian dollars

Code
BIA-D2554
Synonyms
6-Desmethylgriseofulvin, 6-O-Demethyl Griseofulvin
CAS #
20168-88-1
Molecular Formula
C16H15ClO6
Molecular Weight
338.74
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

6-O-Demethylgriseofulvin is one of two demethyl metabolites of griseofulvin produced by oxidative metabolism in vivo. Griseofulvin is a potent antifungal that acts by binding to fungal tubulin and inhibiting the mitotic spindle.

References

  • Synthesis in the griseofulvin series. III. Chloro analogs and 6'-​demethylgriseofulvin. Taub D. et al. Angewandte Chemie 1962, 74, 586.
  • Oxidative demethylation of carbon-​14-​labeled griseofulvin by liver microsomes of rats and mice. Chang R.L. et al. Biochem Pharmacol. 1973, 22, 1389.
  • Griseofulvin inhibits fungal mitosis. Gull K. & Trinci A.P.J. Nature 1973, 244, 292.

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