Deacetylravidomycin

Deacetylravidomycin

$310.00 - 0.50 mg

$1,085.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-D1074
Synonyms
AY 26623
CAS #
88580-27-2
Molecular Formula
C29H31NO8
Molecular Weight
521.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

O-Deacetylravidomycin is the more active and stable analogue of the ravidomycin complex produced by Streptomyces ravidus. The metabolite shows potent, light-dependent antitumor activity. O-Deacetylravidomycin, like the related gilvocarcins and chrysomycins, is thought to act as a topoisomerase II inhibitor.

References

  • New ravidomycin analogues, FE35A and FE35B, apoptosis inducers produced by Streptomyces rochei. Yamashita N. et al., J. Antibiot. 1998, 51, 1105.
  • Biochemical characterisation of elsamicin and other coumarin-related antitumor agents as potent inhibitors of human topoisomerase II. Lorico A. et al., Eur. J. Cancer 1993, 29A, 1985.
  • Light-dependent activity of the antitumor antibiotics ravidomycin and desacetylravidomycin. Greenstein M. et al., Antimicrob. Agents Chemother. 1986, 29, 861.

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