$270.00 - 1 mg
$945.00 - 5 mg
All prices in Australian dollars
- LY 146032
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Daptomycin is a member of the A 21978 complex of high molecular weight cyclic lipopeptides with potent antibiotic activity, notably against MRSA, VISA and VRSA bacterial strains. Originally isolated from Streptomyces roseosprous by Eli Lily in the 1980s, daptomycin was selected and developed by Cubist Pharmaceuticals for human use. Daptomycin exhibits Ca-dependent depolarisation of the bacterial membrane resulting in loss of membrane potential leading to inhibition of DNA, RNA and protein synthesis which results in cell death.
- Role of branched chain fatty acid precursors in regulation factor profile in the biosynthesis of A21978 C complex. Zmijewski M. J. et al., J. Antibiotics 1986, 39, 1483.
- Complex of new acidic peptide antibiotics. Isolation, chemistry, and mass spectral structure elucidation. Debono M. et al., J. Antibiotics 1987, 40, 761.
- Daptomycin: a lipopeptide antibiotic for the treatment of serious Gram positive infections. Steenbergen J.N. et al., J. Antimicrobial Chemotherapy 2005, 55, 283.