$290.00 - 1 mg
$1,015.00 - 5 mg
All prices in Australian dollars
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Dalfopristin is a semi-synthetic analogue of ostreogrycin A (virginiamycin M, pristinamycin IIA, streptogramin A) formed by addition of diethylaminoethylthiol to the 2-pyrroline group of ostreogrycin, followed by oxidation to the sulfone. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Dalfopristin is used commercially in synergistic combination with quinupristin (70:30). There is little published data on the synthesis, biological or antibiotic activity of dalfopristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.
- Quinupristin/dalfopristin (RP 59500): A new streptogramin antibiotic. Chant C. et al., Ann. Pharm. 1995, 29,1022.
- Quinupristin/dalfopristin: spectrum of activity, pharmacokinetics, and initial chemical experience. Low D. Microb. Drug Resist. 1995, 1, 223.
- Quinupristin/dalfopristin: a therapeutic review. Allington D.R. & Rivey M.P. Clin. Ther. 2001, 23, 24.