Cyclopiazonic acid

Cyclopiazonic acid

$95.00 - 1 mg

$335.00 - 5 mg

All prices in Australian dollars

Code
BIA-C1244
CAS #
18172-33-3
Molecular Formula
C20H20N2O3
Molecular Weight
336.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Product Data Sheet

Application Notes

Cyclopiazonic acid is a tremorigenic indole produced by several species of Aspergillus and Penicillium. Cyclopiazonic acid is a highly specific inhibitor of calcium ATPase of sarcoplasmic reticulum, altering calcium homeostasis and ATP-dependent calcium transport and resulting in the release of intracellular stored Ca2+ without increasing IP3.

References

  • The isolation and structure of cyclopiazonic acid, a toxic metabolite of Penicillium cyclopium Westling. Holzapfel C. W. Tetrahedron 1968, 24, 2101.
  • Cyclopiazonic acid and related toxins. Holzapfel C. W. In A. Ciegler, S. Kadis and S. J. Ajl (ed.) Microbial toxins, vol. VI. Academic Press Inc., New York. 1971, 435.
  • Isolation of cyclopiazonic acid, cyclopiazonic acid imine and bissecodehydrocyclopiazonic acid from the cultures of Aspergillus versicolor (Vuill.) Tiraboshi. Ohmono S. et al., J. Agric. Chem.Soc. 1973, 47, 57.
  • Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum. Seidler N. W. et al., J. Biol. Chem. 1989, 264, 17816.

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