Cyclopiazonic acid is a tremorigenic indole produced by several species of Aspergillus and Penicillium. Cyclopiazonic acid is a highly specific inhibitor of calcium ATPase of sarcoplasmic reticulum, altering calcium homeostasis and ATP-dependent calcium transport and resulting in the release of intracellular stored Ca2+ without increasing IP3.
- The isolation and structure of cyclopiazonic acid, a toxic metabolite of Penicillium cyclopium Westling. Holzapfel C. W. Tetrahedron 1968, 24, 2101.
- Cyclopiazonic acid and related toxins. Holzapfel C. W. In A. Ciegler, S. Kadis and S. J. Ajl (ed.) Microbial toxins, vol. VI. Academic Press Inc., New York. 1971, 435.
- Isolation of cyclopiazonic acid, cyclopiazonic acid imine and bissecodehydrocyclopiazonic acid from the cultures of Aspergillus versicolor (Vuill.) Tiraboshi. Ohmono S. et al., J. Agric. Chem.Soc. 1973, 47, 57.
- Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum. Seidler N. W. et al., J. Biol. Chem. 1989, 264, 17816.