Conglobatin

Conglobatin

$245.00 - 0.50 mg

$858.00 - 2.50 mg

All prices in Australian dollars

CAS #
72263-05-9
Molecular Formula
C28H38N2O6
Molecular Weight
498.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Clear

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Application Notes

Isolated from Streptomyces conglobatus, conglobatin has a unusual dimeric macrolide dilactone structure with pendant oxazole groups. Conglobatin exhibits an IC50 of 0.63 μg/ml in a NFAT-dependant transcription assay. No toxicity was observed at doses up to 1000 mg/kg when administered to mice either orally or interperitoneally.

References

  • Conglobatin, a novel macrolide dilactone from Streptomyces conglobatus ATCC 31005. Westley J.W. et al., J. Antibiot. 1979, 32, 874.
  • Simple aromatics identified with a NFAT-lacZ transcription assay for the detection of immunosuppressants. Burres N.E. et al., J. Antibiot. 1995, 48, 380.

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