Conglobatin
Conglobatin
$265.00 - 0.50 mg
$930.00 - 2.50 mg
All prices in Australian dollars
- Code
- BIA-C1022
- CAS #
- 72263-05-9
- Molecular Formula
- C28H38N2O6
- Molecular Weight
- 498.6
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Download Data Sheets
Application Notes
Isolated from Streptomyces conglobatus, conglobatin has a unusual dimeric macrolide dilactone structure with pendant oxazole groups. Conglobatin exhibits an IC50 of 0.63 μg/ml in a NFAT-dependant transcription assay. No toxicity was observed at doses up to 1000 mg/kg when administered to mice either orally or interperitoneally.
References
- Conglobatin, a novel macrolide dilactone from Streptomyces conglobatus ATCC 31005. Westley J.W. et al., J. Antibiot. 1979, 32, 874.
- Simple aromatics identified with a NFAT-lacZ transcription assay for the detection of immunosuppressants. Burres N.E. et al., J. Antibiot. 1995, 48, 380.
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