Cochlioquinone B

Cochlioquinone B

$295.00 - 0.50 mg

$1,035.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-C1020
CAS #
32450-26-3
Molecular Formula
C28H40O6
Molecular Weight
472.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Cochlioquinone B, the minor component of a bioactive pigment isolated from Bipolaris leersia, is an NADH-ubiquinone reductase inhibitor and phytotoxic agent inhibiting root growth. It is closely related to Cochlioquinone A which inhibits diacylglycerol acyltransferase and exhibits anti-angiogenic and nematocidal activity. Cochlioquinones have recently been shown to be antagonists of the human chemokine receptor, CCR5, in HIV-1.

References

  • Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum. Yoganathan K., et al., J. Antibiot., 2004, 57, 59.
  • Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola. Jung H. J. et al., Bioorg. Med. Chem., 2003, 11, 4743.
  • Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1. Lee H. B. et al., J. Antibiot., 2003, 56, 967.

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