Cochlioquinone A

Cochlioquinone A

$295.00 - 0.50 mg

$1,035.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-C1019
Synonyms
Luteoleersin
CAS #
32450-25-2
Molecular Formula
C30H44O8
Molecular Weight
532.7
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Cochlioquinone A is the major component of a bioactive pigment isolated from Bipolaris leersia. Cochlioquinone A has recently been shown to be an antagonist of the human chemokine receptor, CCR5, in HIV-1. Cochlioquinone A is anti-angiogenic and exhibits inhibitory activity against diacylglycerol acyltransferase and NADH-ubiquinone reductase.

References

  • Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum. Yoganathan K., et al., J. Antibiot. 2004, 57, 59.
  • Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola. Jung H.J. et al., Bioorg. Med. Chem. 2003, 11, 4743.
  • Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1. Lee H.B. et al., J. Antibiot. 2003, 56, 967.

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