Chuangxinmycin was isolated from Actinoplanes tsinanensis by researchers at the Institute of Antibiotics, Chinese Academy of Medical Sciences in 1977. Chuangxinmycin contains a unique indole-dihydrothiopyran heterocyclic core structure, derived from L-tryptophan. Chuangxinmycin is potently active against Gram-positive and Gram-negative bacteria and has antiviral activity. Chuangxinmycin is a potent and selective inhibitor of bacterial tryptophanyl tRNA synthase and has dose-dependent antiinflammatory effects in mice in vivo.