Chrysomycin B

Chrysomycin B

$315.00 - 0.50 mg

$1,105.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-C1018
Synonyms
Chrysomycin M, Virenomycin M, Albacarcin M
CAS #
83852-56-6
Molecular Formula
C27H28O9
Molecular Weight
496.5
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Chrysomycin B is a minor analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl analogue (Chrysomycin A), albeit still a potent antitumor active and an inhibitor of the catalytic activity of human topoisomerase II. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated cross-linkers of DNA to histones.

References

  • Biochemical characterisation of elsamicin and other coumarin-related antitumor agents as potent inhibitors of human topoisomerase II. Lorico A. et al., Eur. J. Cancer. 1993, 29A, 1985.
  • Chrysomycin derivative compounds and use as antitumor agents. US Patent 6,030,951, 2000.
  • Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblasts. Matsumoto A. et al., Cancer Res. 2000, 60, 3921.

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