Chromomycin A3

Chromomycin A3

$120.00 - 1 mg

$420.00 - 5 mg

All prices in Australian dollars

Code
BIA-C1240
Synonyms
Aburamycin, Toyomycin, NSC 58514, B 599-III, SR1768E
CAS #
7059-24-7
Molecular Formula
C57H82O26
Molecular Weight
1183.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Product Data Sheet

Application Notes

Chromomycin A3 is the major component of the chromomycin complex of the aureolic acid class, isolated from several Streptomyces species, and first reported in 1960. Chromomycin A3 exhibits a broad biological profile as an antibacterial, antifungal and antitumor agent. It binds reversibly to GC-specific DNA ligand in the minor groove which inhibits transcription, DNA gyrase and topoisomerase II activity. The intense UV spectrum and strong fluorescence makes chromomycin a useful stain for DNA.

References

  • Studies on streptomycetes. On a new antibiotic, chromomycin. Shibata M. et al., J. Antibiotics Ser. B, 1960, 13, 1.
  • Aureolic acid group of anti-tumor antibiotics. Berlin Y. A. Nature 1968, 218, 193.
  • Transcriptional regulation of differentiation, selective toxicity and ATGCAAAT binding of bisbenzimidazole derivatives in human melanoma cells. Wong S. et al., Biochem. Pharmacol. 1994, 47, 827.

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