Chevalone C
Application Notes
Chevalone C is a meroterpenoid metabolite isolated from the fungus, Eurotium chevalieri, by Thai researchers in 2011. The pentacyclic ring system of chevalone C is formed from closure of ring D by coupling the 2-hydroxy pyrone tautomer to the exo-alkene. This gives chevalone C a distinctly different UV spectrum from chevalones A and B which couple through the 4-hydroxypyrone tautomer. The ring closure to form chevalone C can also be achieved by acid catalysis of aszonapyrone A. Chevalone C has weak activity against mycobacteria and some tumor cell lines.
References
- Bioactive meroterpenoids and alkaloids from the fungus Eurotium chevalieri. Kanokmedhakul K. et al., Tetrahedron 2011, 67, 5461.