Chaetocin

Chaetocin

$310.00 - 1 mg

$1,085.00 - 5 mg

All prices in Australian dollars

Code
BIA-C1146
Synonyms
Chetocin
CAS #
28097-03-2
Molecular Formula
C30H28N6O6S4
Molecular Weight
696.9
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in 50% chloroform in methanol.

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Product Data Sheet

Application Notes

Chaetocin is an epithiodioxopiperazine antibiotic that has recently shown promise as a selective antitumor agent. Chaetocin is an inhibitor of lysine-specific methyltransferase SU(VAR)3-9 both in vitro and in vivo. Chaetocin is dramatically accumulated in cancer cells via a process inhibited by glutathione. Inside the cell, its activity is mediated by the imposition of oxidative stress.

References

  • Isolation and configuration of Chaetocin. Hauser, D. et al., Helv. Chim. Acta 1970, 53, 1061.
  • Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Greiner D. et al., Nature Chem. Biol. 2005, 1, 143.
  • Chaetocin, a promising new anti-myeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress. Isham C.R. et al., Blood 2007, 109, 2579.

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