Caspofungin acetate
Caspofungin acetate
$290.00 - 1 mg
$1,015.00 - 5 mg
All prices in Australian dollars
- Code
- BIA-C1239
- Synonyms
- Cancidas, L-743,872, MK-0991
- CAS #
- 179463-17-3
- Molecular Formula
- C52H88N10O15•2C2H4O2
- Molecular Weight
- 1213.4
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in water and methanol or DMSO. Slightly soluble in ethanol.
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Application Notes
Caspofungin is a semi-synthetic analogue of pneumocandin B0 with improved water solubility, a significant limitation in the development of the echinocandin class as pharmaceuticals. Caspofungin acts by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.
References
- Synthesis and antifungal activity of novel cationic pneumocandin B0 derivatives. Bouffard F. A. et al., 1994. J. Med. Chem. 1994, 37, 222.
- The fungal cell wall as a drug discovery target: SAR of novel echinocandin analogs. Balkovec J. M. Pharmacochemistry Library 1997, 28, 1.
- In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872). Bartizal K. et al., Antimicrob. Agents Chemother. 1997, 41, 2326.
- Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743872). Hajdu R. et al., Antimicrob. Agents Chemother. 1997, 41, 2339.