Capreomycin

Capreomycin

$145.00 - 5 mg

$510.00 - 25 mg

All prices in Australian dollars

Code
BIA-C1454
Synonyms
Capromycin, Caprolin, Capastat, Capostatin, L 29275
CAS #
11003-38-6
Molecular Formula
C25H44N14O7 (for IB)
Molecular Weight
652.7 (for IB)
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Good water solubility.

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Application Notes

Capreomycin is a complex of cyclic pentopeptides isolated from Streptomyces capreolus, first reported in 1962. The complex has two major components, IA and IB, with an exocyclic lysine residue and two minor delysinyl components, IIA and IIB. Capreomycin is a potent antibiotic with activity against mycobateria, Gram positive and Gram negative organisms. Capreomycin acts by binding to the 23S ribosomal subunit, disrupting protein synthesis.

References

  • Chemical and biological properties of capreomycin and other peptide antibiotics. Herr E.B. Antimicrob. Agents Chemother. 1962, 1963, 201.
  • Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin. Akbergenov R. et al., Antimicrob. Agents Chemother. 2011, 55, 4712.

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