Candicidin complex

Candicidin complex

$295.00 - 1 mg

$1,035.00 - 5 mg

All prices in Australian dollars

Code
BIA-C1564
Synonyms
Levorin
CAS #
1403-17-4
Molecular Formula
C59H84N2O18 (for Candicidin D)
Molecular Weight
1109.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Poorly soluble in most organic solvents. Soluble in tetrahydrofuran 80% aqueous.

Download Data Sheets

Product Data Sheet

Application Notes

Candicidin is a macrocyclic heptaene antifungal complex produced by Streptomyces griseus and isolated by Lechevalier and colleagues in 1953. The candicidin complex comprises analogues A, B, C and D, with candicidin D as the major component. Candicidin is active against fungi, in particular Candida albicans, and is used clinically to treat vaginal candidiasis. Like all polyene antifungal metabolites, candicidin acts by binding to ergosterol and disrupting the fungal membrane.

References

  • Candicidin, a new antifungal antibiotic. Lechevalier H. et al., Mycologia 1953, 45, 155.
  • On Streptomyces producing a new antifungal substance mediocidin and antifungal substances of fungicidin-rimocidin-chromin group, eurocidin group and trichomycin-ascosin-candicidin group. Okami Y. et al., J. Antibiot. 1954, 7, 98.
  • Candicidin and other polyenic antifungal antibiotics. Waksman S.A. et al., Bull. World Health Organ. 1965, 33, 219.

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