Butyrolactone I
Butyrolactone I
$210.00 - 1 mg
$735.00 - 5 mg
All prices in Australian dollars
- Code
- BIA-B1406
- Synonyms
- Olomoucin
- CAS #
- 87414-49-1
- Molecular Formula
- C24H24O7
- Molecular Weight
- 424.5
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Download Data Sheets
Application Notes
Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I exhibits antitumor activity, inhibiting the cell cycle at the G1/S and G2/M transitions. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs.
References
- Metabolic products of Aspergillus terreus. IX. Biosynthesis of butyrolactone derivatives isolated from strains IFO 8835 and 4100. Nitta K. et al., Chem. Pharm. Bull. 1983, 31, 1528.
- Butyrolactone I induces cyclin B1 and causes G2/M arrest and skipping of mitosis in human prostate cell lines. Suzuki M. et al., Cancer Lett. 1999, 138, 121.
- Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase. Kitagawa M. et al., Oncogene 1993, 8, 2425.