Butyrolactone I

Butyrolactone I

$210.00 - 1 mg

$735.00 - 5 mg

All prices in Australian dollars

Code
BIA-B1406
Synonyms
Olomoucin
CAS #
87414-49-1
Molecular Formula
C24H24O7
Molecular Weight
424.5
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Product Data Sheet

Application Notes

Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I exhibits antitumor activity, inhibiting the cell cycle at the G1/S and G2/M transitions. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs.

References

  • Metabolic products of Aspergillus terreus. IX. Biosynthesis of butyrolactone derivatives isolated from strains IFO 8835 and 4100. Nitta K. et al., Chem. Pharm. Bull. 1983, 31, 1528.
  • Butyrolactone I induces cyclin B1 and causes G2/M arrest and skipping of mitosis in human prostate cell lines. Suzuki M. et al., Cancer Lett. 1999, 138, 121.
  • Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase. Kitagawa M. et al., Oncogene 1993, 8, 2425.

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