Burnettramic acid A

Burnettramic acid A

$158.00 - 0.25 mg

$553.00 - 1 mg

All prices in Australian dollars

CAS #
2334483-46-2
Molecular Formula
C41H71NO12
Molecular Weight
770
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

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Application Notes

Burnettramic acid A and its aglycone are members of a new class of antibiotics from an Australian fungus Aspergillus burnettii.  The rare bolaamphiphilic scaffold consists of β-​d-​mannose linked to a pyrrolizidinedione unit via a 26-​carbon chain. Burnettramic acid A is active against the Gram positive bacteria, B. subtilis and S. aureus, with IC50 2.3 and 5.9 µg/mL, respectively. Burnettramic acid A is a potent antifungal agent (IC50 0.5 µg/mL and 0.2 µg/mL against C. albicans and S. cerevisiae, respectively). Burnettramic acid A is also active against murine myeloma NS-1 cell line (IC50 13.8 µg/mL). Removal of the glycosyl group negates antibiotic and antifungal activity, but not activity against murine myeloma cell line (IC50 8.5 µg/mL for the aglycone).

References

  • Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-​NRPS-​Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii. Hang L. et al. Org lett 2019, 21, 1287.
  • Comprehensive chemotaxonomic and genomic profiling of a biosynthetically talented Australian fungus, Aspergillus burnettii sp. nov. Gilchrist C. et al. FG & B 2020, 143, 103435.  

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