Betulinic acid

Betulinic acid

Betulinic acid

$70.00 - 1 mg

$245.00 - 5 mg

All prices in Australian dollars

Code
BIA-B1758
Synonyms
(+)-Betulinic acid, Betulic acid, Lupatic acid, NSC 113090, β-Betulinic acid
CAS #
472-15-1
Molecular Formula
C30H48O3
Molecular Weight
456.7
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol, DMSO.

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Product Data Sheet

Application Notes

Betulinic acid is a pentacyclic lupane terpene, first published in 1917. Betulinic acid is isolated as a constituent of various tree species, including birch. Betulinic acid has antiviral, antibacterial, antimalarial, antiinflammatory, anthelmintic and antinociceptive properties. Betulinic acid induces apoptosis via caspase activation and also disrupts the mictochondrial membrane, induces DNA fragmentation and suppresses aerobic glycolysis via interaction with Cav-1. Derivatives of betulinic acid are active against bacterial biofilms.

References

  • Chemical studies of the Myrtaceae. II. The constituents of Syncarpia laurifolia Tenn. Hodgson D. et al., Aust. J. Chem. 1960, 13, 385.
  • Betulinic acid and its derivatives: A review on their biological properties. Yogeeswari P. & Sriram D., Curr. Med. Chem. 2005, 12, 657.
  • Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway. Jiao L. et al., Biochem. Pharmacol. 2019, 161, 149.

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