Benzomalvin B

Benzomalvin B

$233.00 - 1 mg

$816.00 - 5 mg

All prices in Australian dollars

Code
BIA-B1646
CAS #
157047-97-7
Molecular Formula
C24H17N3O2
Molecular Weight
379.41
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
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Application Notes

Benzomalvin B was first isolated as a weakly active inhibitor of substance P from mammalian neurokinin NK1 receptors by researchers at Sterling Winthrop Pharmaceuticals (now Sanofi Aventis) in 1994. The core benzodiazepine structure of benzomalvin B is formed biosynthetically by the condensation of two molecules of anthranilic acid and phenylalanine. Benzomalvin B is related to the asperlicins, potent and selective antagonists of peripheral cholecystokinin receptors. Lack of availability has hampered further exploration of the pharmacology of benzomalvin B.

References

  • Benzomalvins, new substance P inhibitors from a Penicillium sp. Sun H.H. et al., J. Antibiot. 1994, 47, 515.
  • The first total synthesis of (-)-benzomalvin A and benzomalvin B via the intramolecular aza-Wittig reactions. Sugimori T. et al., Tetrahedron 1998, 54, 7997.
  • Asperlicin, a novel non-peptidal cholecystokinin antagonist from Aspergillus alliaceus. Fermentation, isolation and biological properties. Goetz M.A. et al., J. Antibiot. 1985, 38, 1633.

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