Bafilomycin C1

Bafilomycin C1

$205.00 - 1 mg

$718.00 - 5 mg

All prices in Australian dollars

Code
BIA-B1111
Synonyms
L-681, 110A1
CAS #
88979-61-7
Molecular Formula
C39H60O12
Molecular Weight
720.9
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility. NOTE: forms methyl ketal on long term storage in methanol.
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Application Notes

Bafilomycin C1 is a member of a potent family of macrocyclic lactones. Bafilomycin C1 shares a similar mode of action and activity as its more accessible A1 analogue. Bafilomycin C1 is broadly active against bacteria, fungi, insects, nematodes and cestodes. Bafilomycin C1 has attracted interest as a potential agent for treating osteoporosis. The presence of the fumarate group provides an ideal ligand for affinity chromatography of V-ATPase.

References

  • Bafilolides, Potent Inhibitors of the Motility and Development of the Free-Living Stages of Parasitic Nematodes. Lacey E. et al., Int. J. Parasitol. 1995, 25, 349.
  • Purification of Vacuolar ATPase with Bafilomycin C1 Affinity Chromatography. Rautiala T.J. et al., Biochem. Biophys. Res. Comm. 1993, 194, 50.
  • Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of osteolysis. Xu J. et al., Histol. Histopathol. 2007, 22, 443.

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