Bafilomycin A1

Bafilomycin A1

$270.00 - 1 mg

$945.00 - 5 mg

All prices in Australian dollars

Code
BIA-B1012
CAS #
88899-55-2
Molecular Formula
C35H58O9
Molecular Weight
622.8
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility. NOTE: forms methyl ketal on long term storage in methanol.
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Application Notes

Bafilomycin A1 is a member of a potent family of macrocyclic lactones with broad spectrum biological activity, including activity against bacteria, yeast, fungi, nematodes, insects and tumor cell lines. Bafilomycin A1 is an inhibitor of vacuolar-type ATPase.

References

  • Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Bowman E.J. et al., Proc Natl Acad Sci USA. 1988, 85, 7972.
  • Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. Yoshimori T. et al., J Biol Chem. 1991, 266, 17707.
  • Vacuolar ATPase as a drug discovery target. Niikura K. Drug News Perspect. 2006, 19, 139.

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