Azamulin

Azamulin

$215.00 - 1 mg

$753.00 - 5 mg

All prices in Australian dollars

Code
BIA-A1489
Synonyms
TMD 85-530, SA 85530b
CAS #
76530-44-4
Molecular Formula
C24H38N4O4S
Molecular Weight
478.7
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Clear

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Application Notes

Azamulin is a semi-synthetic pleuromutilin prepared by sequential reaction of dihydropleuromutilin tosylate with 2-amino-1,2,4-triazole-5-thiol. While azamulin is a broad spectrum antibiotic in the pleuromutilin class, this aspect of its bioprofile has received little attention. In fact, the triazole substituent added to nominally improve the drug's bioavailability, imparted an unusual selectivity for the inhibition of specific cytochrome P450 mixed function oxidase sub-types, important for understanding the manner in which the body metabolises drugs or xenobiotics.

References

  • A comparative study of 1-substituted imidazole and 1,2,4-triazole antifungal compounds as inhibitors of testosterone hydroxylations catalysed by mouse hepatic musomal cytochromes P-450 Ballard, S. et al., Biochem. Pharmacol. 1988, 37, 4643.

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