Avrainvillamide

Avrainvillamide

$199.00 - 0.25 mg

$697.00 - 1 mg

All prices in Australian dollars

Code
BIA-A1965
Synonyms
(+)-Avrainvillamide, CJ 17665
CAS #
269741-97-1
Molecular Formula
C26H27N3O4
Molecular Weight
445.51
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

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Application Notes

Avrainvillamide is the monomer of the stephacidin B dimer. Avrainvillamide is active against the proto-oncogene, mutated NPM1, commonly present in patients with acute myeloid lukemia. Avrainvillamide alkylates Cys275 of mutated NPM1, inhibits nuclear export of Crm1 cargo proteins.  Aavrainvillamide also displaces Thr199-​phosphorylated NPM1 from duplicated centrosomes, leads to an accumulation of supernumerary centrosomes and inhibits dephosphorylation of Thr199-​phosphorylated NPM1 by protein phosphatase 1.  

References

  • A new antibiotic CJ-17,665 from Aspergillus ochraceus. Sugie Y. et al. J Antibiot. 2001, 54, 911.
  • The natural product avrainvillamide binds to the oncoprotein nucleophosmin. Wulff J.E. et al. J Am Chem Soc 2007, 129, 14444.
  • Anti-​proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia. Vibeke A. et al. Cell death & disease 2016, 7, e2497.

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