Avilamycin C is a chlorine-containing polysaccharide antibiotic produced by Streptomyces viridochromogenes. Avilamycin is active against Gram-positive bacteria and is used as a growth promotant and for prevention of necrotic enteritis in animals. Avilamycin binds to the 30S ribosome and resistance is conferred by rNA methyl transferases. Avilamycin C is a major analogue in the commercial product SurmaxTM.
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- Avilamycin, an inhibitor of the 30 S ribosomal subunits function. Wolf H. FEBS Lett 1973, 36, 181.
- An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57. Weitnauer G. et al. Antimicrob Agents Chemother 2001, 45, 690.