Avermectin B1a, epi-

Avermectin B1a, epi-

$290.00 - 1 mg

$1,015.00 - 5 mg

All prices in Australian dollars

Code
BIA-A1576
CAS #
106434-14-4
Molecular Formula
C48H72O14
Molecular Weight
873.1
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
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Application Notes

epi-Avermectin B1a is a base-catalysed intermediate in the decomposition of avermectin B1a. epi-Avermectin B1a is formed by epimerisation at the 2-position which ultimately rearranges irreversibly to the isomeric alkene analogue, Δ2-avermectin B1a. epi-Avermectin B1a is only very weakly active as a nematocide showing ~100-fold loss of biological activity compared with the parent avermectin. epi-Avermectin B1a is formed in vivo following treatment with avermectin and is an environmental degradation product.

References

  • Base-catalyzed isomerization of avermectins. Pivnichny J.V. et al., J. Agric. Food Chem. 1988, 36, 826.
  • Direct determination of avermectins in plasma at nanogram levels by High-Performance Liquid Chromatography. Pivnichny J.V. et al., J. Pharm. Sci. 1980, 72, 1447.

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