Avermectin B1a, epi-
Avermectin B1a, epi-
$315.00 - 1 mg
$1,105.00 - 5 mg
All prices in Australian dollars
- Code
- BIA-A1576
- CAS #
- 106434-14-4
- Molecular Formula
- C48H72O14
- Molecular Weight
- 873.1
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in ethanol, methanol, DMF or DMSO.
Download Data Sheets
Application Notes
epi-Avermectin B1a is a base-catalysed intermediate in the decomposition of avermectin B1a. epi-Avermectin B1a is formed by epimerisation at the 2-position which ultimately rearranges irreversibly to the isomeric alkene analogue, Δ2-avermectin B1a. epi-Avermectin B1a is only very weakly active as a nematocide showing ~100-fold loss of biological activity compared with the parent avermectin. epi-Avermectin B1a is formed in vivo following treatment with avermectin and is an environmental degradation product.
References
- Base-catalyzed isomerization of avermectins. Pivnichny J.V. et al., J. Agric. Food Chem. 1988, 36, 826.
- Direct determination of avermectins in plasma at nanogram levels by High-Performance Liquid Chromatography. Pivnichny J.V. et al., J. Pharm. Sci. 1980, 72, 1447.
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