Austdiol

Austdiol

$250.00 - 1 mg

$875.00 - 5 mg

All prices in Australian dollars

Code
BIA-A2935
CAS #
53043-28-0
Molecular Formula
C12H12O5
Molecular Weight
236.22
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
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Application Notes

Austdiol is an azaphilone pigment produced by Aspergillus ustus found in cereals feed grain first reported Steyn and co-workers at CSIR, South Africa in 1974. Austdiol is a trans-vicinal diol in which the two fused rings lie in approximately the same plane. Austdiol induces cell cycle arrest in G2/M phase, inducing DNA breaks and increasing the frequency of micronuclei and nucleoplasmic bridges in binucleated cells in a CHO-K1 cell line. Austdiol is mutagenic and carcinogenic.

References

  • Constitution and absolute configuration of austdiol, the main toxic metabolite from Aspergillus ustus. Vleggaar R. et al. J Chem Soc Perkin Transaction 1, 1974, 45.
  • The fungal metabolite austdiol. Lo Presti L. et al. Acta Crystallographica, Section C: Crystal Structure Communications (2003), C59, 4.
  • The effects of the mycotoxin austdiol on cell cycle progression, cytotoxicity and genotoxicity in Chinese hamster ovary (CHO-K1) cells. Franchi L.P. et al. World Mycotox J 2016, 9, 237.

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