Austdiol

Austdiol

$285.00 - 1 mg

$1,000.00 - 5 mg

All prices in Australian dollars

Code
BIA-A2935
CAS #
53043-28-0
Molecular Formula
C12H12O5
Molecular Weight
236.22
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Austdiol is an azaphilone pigment produced by Aspergillus ustus found in cereals feed grain first reported Steyn and co-workers at CSIR, South Africa in 1974. Austdiol is a trans-vicinal diol in which the two fused rings lie in approximately the same plane. Austdiol induces cell cycle arrest in G2/M phase, inducing DNA breaks and increasing the frequency of micronuclei and nucleoplasmic bridges in binucleated cells in a CHO-K1 cell line. Austdiol is mutagenic and carcinogenic.

References

  • Constitution and absolute configuration of austdiol, the main toxic metabolite from Aspergillus ustus. Vleggaar R. et al. J Chem Soc Perkin Transaction 1, 1974, 45.
  • The fungal metabolite austdiol. Lo Presti L. et al. Acta Crystallographica, Section C: Crystal Structure Communications (2003), C59, 4.
  • The effects of the mycotoxin austdiol on cell cycle progression, cytotoxicity and genotoxicity in Chinese hamster ovary (CHO-K1) cells. Franchi L.P. et al. World Mycotox J 2016, 9, 237.

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