Austdiol is an azaphilone pigment produced by Aspergillus ustus found in cereals feed grain first reported Steyn and co-workers at CSIR, South Africa in 1974. Austdiol is a trans-vicinal diol in which the two fused rings lie in approximately the same plane. Austdiol induces cell cycle arrest in G2/M phase, inducing DNA breaks and increasing the frequency of micronuclei and nucleoplasmic bridges in binucleated cells in a CHO-K1 cell line. Austdiol is mutagenic and carcinogenic.
- Constitution and absolute configuration of austdiol, the main toxic metabolite from Aspergillus ustus. Vleggaar R. et al. J Chem Soc Perkin Transaction 1, 1974, 45.
- The fungal metabolite austdiol. Lo Presti L. et al. Acta Crystallographica, Section C: Crystal Structure Communications (2003), C59, 4.
- The effects of the mycotoxin austdiol on cell cycle progression, cytotoxicity and genotoxicity in Chinese hamster ovary (CHO-K1) cells. Franchi L.P. et al. World Mycotox J 2016, 9, 237.