Armeniaspirol A

Armeniaspirol A

$189.00 - 0.25 mg

$662.00 - 1 mg

All prices in Australian dollars

Molecular Formula
Molecular Weight
>95% by HPLC
Long Term Storage
Soluble in ethanol, methanol, DMF or DMSO.

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Application Notes

Armeniaspirol A is a major component of the complex produced by Streptomyces armeiacus, discovered by researchers at Sanofi in 2012. Armeniaspirols are a novel class of antibiotics with a unique chlorinated spiro[4.4]non-8-ene scaffold, potently active against Gram-positive pathogens including MRSA and VRE. Armeniaspirol A is a protonophore disrupting the membrane potential and decreases oxygen consumption in mitochondria. Armeniaspirol A inhibits the ATP-dependent proteases ClpXP and ClpYQ in vitro and in the model Gram-positive Bacillus subtilis. The pyrrole chloro group and the methyl group appear to be important for antimicrobial activities. Armeniaspirol A is also active against H. pylori.


  • Isolation and structural elucidation of armeniaspirols A–C: Potent antibiotics against Gram-positive pathogens. Dufour C. et al. Chem Eur J 2012, 18, 16123.
  • Characterization of the biosynthetic gene cluster for the antibiotic armeniaspirols in Streptomyces armeniacus. Qiao Y. et al. J Nat Prod 2019, 82, 318.
  • Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria. Labana P. et al. Cell Chem Biol 2021, 28, P1703.
  • Armeniaspirol A: a novel anti-Helicobacter pylori agent. Jia J. et al. Microb Biotechnol 2022, 15, 442.

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