Aquastatin A

Aquastatin A

$215.00 - 0.50 mg

$755.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-A2564
CAS #
153821-50-2
Molecular Formula
C36H52O12
Molecular Weight
676.79
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

Aquastatin A, produced by Fusarium sp., is an inhibitor of mammalian adenosine triphosphatases with an IC50 of 7.1 µM against Na+/K+-ATPase 6.2 µM against H+/K+-ATPase. Aquastatin A is a potent inhibitor of enoyl-ACP reductase (FabI) of Staphylococcus aureus and is active against MRSA. Aquastatin A was patented for the treatment of gastric ulcers in 1994.

References

  • Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological properties. Hamano K. et al. J Antibiot 1993, 46, 1648.
  • Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611. Kwon Y-J. Biol Pharm Bull 2009, 32, 2061.
  • Aquastatin A manufacture with Fusarium for use in treatment of gastric ulcers. Hamano K. et al. Jpn. Kokai Tokkyo Koho 1994, JP 06247900 A 19940906.

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