Aquastatin A, produced by Fusarium sp., is an inhibitor of mammalian adenosine triphosphatases with an IC50 of 7.1 µM against Na+/K+-ATPase 6.2 µM against H+/K+-ATPase. Aquastatin A is a potent inhibitor of enoyl-ACP reductase (FabI) of Staphylococcus aureus and is active against MRSA. Aquastatin A was patented for the treatment of gastric ulcers in 1994.
- Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological properties. Hamano K. et al. J Antibiot 1993, 46, 1648.
- Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611. Kwon Y-J. Biol Pharm Bull 2009, 32, 2061.
- Aquastatin A manufacture with Fusarium for use in treatment of gastric ulcers. Hamano K. et al. Jpn. Kokai Tokkyo Koho 1994, JP 06247900 A 19940906.