Aquastatin A

Aquastatin A

$198.00 - 0.50 mg

$695.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-A2564
CAS #
153821-50-2
Molecular Formula
C36H52O12
Molecular Weight
676.79
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

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Application Notes

Aquastatin A, produced by Fusarium sp., is an inhibitor of mammalian adenosine triphosphatases with an IC50 of 7.1 µM against Na+/K+-ATPase 6.2 µM against H+/K+-ATPase. Aquastatin A is a potent inhibitor of enoyl-ACP reductase (FabI) of Staphylococcus aureus and is active against MRSA. Aquastatin A was patented for the treatment of gastric ulcers in 1994.

References

  • Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological properties. Hamano K. et al. J Antibiot 1993, 46, 1648.
  • Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611. Kwon Y-J. Biol Pharm Bull 2009, 32, 2061.
  • Aquastatin A manufacture with Fusarium for use in treatment of gastric ulcers. Hamano K. et al. Jpn. Kokai Tokkyo Koho 1994, JP 06247900 A 19940906.

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