Apooxytetracycline, beta-

Apooxytetracycline, beta-

$150.00 - 1 mg

$525.00 - 5 mg

All prices in Australian dollars

Code
BIA-A1344
Synonyms
β-Apooxytetracycline
CAS #
18751-99-0
Molecular Formula
C22H22N2O8
Molecular Weight
442.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Product Data Sheet

Application Notes

β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. After initial dehydration to anhydrooxytetracycline, it undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-Apooxytetracycline is an important standard for monitoring oxytetracycline stability.

References

  • Reversed-phase high-performance liquid chromatographic method for the assay of oxytetracyline Barnes W.N. et al., J. Chromatog. 1985, 347, 173.
  • Quantitative analysis of oxytetracycline and its impurities by LC-MS-MS. Lykkeberg A.K. et al., Int. J. Pharm. 2004, 34, 325.
  • Terramycin. VI. The structure of 4- and 6-apoterramycin, acid rearrangement products of terramycin. Hochstein F.A. et al., J. Am. Chem. Soc. 1952, 74, 3707.

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