Apicidin
Application Notes
Apicidin is a cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. Apicidin, a histone deacetylase inhibitor, is anti-angiogenic and induces apoptosis.
References
- Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Han J.W. et al., Cancer Res. 2000, 60, 6068.
- Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials. Kim S.H. et al., Biochem. Biophys. Res. Commun. 2004, 315, 964.